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Investigation on Cyp2c19 and Clopidogrel in Bangladeshi Population

Investigation on Cyp2c19 and Clopidogrel in Bangladeshi Population

Paperback
by Muhammad Shahdaat Bin Sayeed   Abul Hasnat  
Language: English
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Book Summary of Investigation on Cyp2c19 and Clopidogrel...

Paperback

The aim of this study was to investigate the allelic distribution of CYP219 genes in Bangladeshi population by using PCR-RFLP method and then the effect of Clopidogrel on Prothrombin Time in different variants of CYP2C19. For genotyping of CYP2C19 alleles blood samples were collected from fifty healthy adult Bangladeshi volunteers. DNA was extracted and PCR-RFLP analysis was employed to genotype CYP2C19*2 and CYP2C19*3. PCR products were digested by Sma I and Bam HI respectively. In case of CYP2C19*2, there were 82% wild variants, 12% heterozygote and 6% mutant variants and in case of CYP2C19*3 there were 98% wild or normal homozygote and 2% heterozygote but there were no mutant variant in our study. Clopidogrel is used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular diseases. Prothombin Time (PT) and International Normalized Ratio (INR) were measured four hours after Clopidogrel 75 mg ingestion. We found increased PT and INR in Homozygote and Heterozygote variants but the statistically significant (P> 0.05) variation was found only in case of Homozygote variants. In case of mutant, we did not find any variation in PT and INR.

 

Details Of Book : Investigation on Cyp2c19 and Clopidogrel...

Book: Investigation on Cyp2c19 and Clopidogrel in Bangladeshi Population
Author:    
ISBN: 3845403403
ISBN-13: 9783845403403
Binding: Paperback
Publishing Date: 2012-04-11
Publisher: LAP Lambert Academic Publishing
Number of Pages: 00172
Language: English
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